3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment

In this study Fusion Deposition Modelling (FDM) was employed to design and fabricate a bilayer tablet consisting of isoniazid (INZ) rifampicin (RFC) for the treatment tuberculosis. INZ formulated in hydroxypropyl cellulose (HPC) matrix allow drug release stomach (acidic conditions) RFC hypromellose acetate succinate (HPMC – AS) upper intestine (alkaline conditions). This may offer better clinical efficacy by minimizing degradation acidic condition potentially avoid drug-drug interaction. The prepared fabricating containing filaments using hot melt extrusion (HME) coupled with 3D printing. HME printing processes were optimised assure consistent deposition drug-containing layers tablet. in-vitro rate varying loading, infilling density, covering layers. Greater than 80% released 45 mins at pH 1.2 approximately 76% releases after dissolution medium changed 7.4. work illustrated potential application FDM technology development oral fixed dose combination personalised treatment.